منابع مشابه
Theiler`s murine encephalomyelitis virus
• natural hosts: wild mice [1], laboratory mice, [2] [3] [4], water , bank and meadow voles (family Microtinae) [5] [6] • positive serological reactions in laboratory rats [7] [8]; virus might be related to TMEV -virus, only one report on clinical signs and lesions in rats (MHG-strain) [9], positive serological findings may indicate the presence of a yet uncharacterised virus (?rat cardiovirus?...
متن کاملChimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence.
Strain GDVII and other members of the GDVII subgroup of Theiler's murine encephalomyelitis virus are highly neurovirulent and rapidly fatal, while strain DA and other members of the TO subgroup produce a chronic, demyelinating disease. GDVII/DA chimeric cDNA studies suggest that a major neurovirulence determinant is within the GDVII 1B through 1D capsid protein coding region, although the addit...
متن کاملTheiler's Murine Encephalomyelitis Virus as a Vaccine Candidate for Immunotherapy
The induction of sterilizing T-cell responses to tumors is a major goal in the development of T-cell vaccines for treating cancer. Although specific components of anti-viral CD8+ immunity are well characterized, we still lack the ability to mimic viral CD8+ T-cell responses in therapeutic settings for treating cancers. Infection with the picornavirus Theiler's murine encephalomyelitis virus (TM...
متن کاملAlternative translation initiation of Theiler's murine encephalomyelitis virus.
DA strain and other members of the TO subgroup of Theiler's murine encephalomyelitis virus (TMEV) produce a chronic demyelinating disease in which the virus persists but has a restricted expression. We previously reported that TO subgroup strains, in addition to synthesizing the picornaviral polyprotein, use an alternative initiation codon just downstream from the polyprotein's AUG to translate...
متن کاملTheiler's murine encephalomyelitis virus-induced cardiac and skeletal muscle disease.
The DA strain of Theiler's murine encephalomyelitis virus, a member of the cardiovirus genus of picornaviruses, induces a restricted and persistent infection associated with a demyelinating process following intracerebral inoculation of mice; both virus infection and the immune response are believed to contribute to the late white matter disease. We now report that intraperitoneal inoculation w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Animals
سال: 1990
ISSN: 0007-5124,1881-7122
DOI: 10.1538/expanim1978.39.4_539